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The Best Mississippi River Cruises to Discover America's Heartland

By Jackie Sheckler Finch

The luxury ships and historic tours are nice, yes. But the real star of Mississippi River cruises has always been the river. There’s nothing quite so Americana as getting to know the many personalities of this 2,350-mile stretch, flowing from northern Minnesota’s Lake Itasca through 10 states until it reaches Louisiana , where the Mississippi River Delta gives way to the Gulf of Mexico.

The slow, meandering journeys of Mississippi River cruises have long proven an ideal way to discover the distinct stories of America’s heartland. In the words of Mark Twain (which no Mississippi River story would be complete without), the towns and cities located on the mighty river's shores are “cheering to the spirit” and “reposeful as a dreamland,” with “nothing to hang a fret or a worry upon.”

The challenge modern travelers now face is when, where, and how to go about this iconic American voyage . Below, see our answers to these frequently asked questions, plus our favorite Mississippi River cruises to book in 2024.

Which cruise lines do Mississippi River cruises?

After American Queen Voyages shut down in February, only two Mississippi River cruise lines currently remain in operation.

Celebrating its 50th anniversary, American Cruise Lines (ACL) has a fleet of more than 20 American-built ships sailing across the country and remains family-owned and American-crewed. ACL offers a Mississippi River fleet of three luxurious 180-passenger modern riverboats– American Melody , American Symphony , and American Serenade —plus two classic paddlewheel ships, the 180-passenger American Splendor and the 150-passenger American Heritage.

The new kid on the Mississippi is the Viking Mississippi, a 386-passenger, five-deck vessel that first set sail in September 2022. The cutting-edge cruise is Viking’s first foray in the US, adding to their fleet of more than 90 ocean, river, and expedition vessels navigating the world’s seven continents.

What is the average cost of a Mississippi River cruise?

For an 8- or 9-day cruise, the average cost of a Mississippi River cruise is around $4,000 per person in a stateroom. Although prices might seem high initially, many of these cruises include extras that aren’t always complimentary on ocean cruises such as free WiFi, at least one free shore excursion in every port, paid port taxes and fees, and a pre-cruise hotel stay. Viking offers complimentary beer, wine, and soft drinks with onboard lunch and dinner. Meanwhile, American Cruise Lines offers complimentary beer, wine, cocktails, and soft drinks. Gratuities are also included in American Cruise Lines fares.

What is the best time of year to go on a river cruise?

Spring (late March through mid-June) and autumn (September through November) are the best times of year to go on a river cruise in the US. Spring blossoms add a colorful touch to the shoreline, and you can never go wrong with autumn foliage. The temperatures are mild, if not pleasantly cool, and passengers are eager to welcome a new spring travel season—or to enjoy one last autumn river adventure before winter arrives.

What month is best for a Mississippi River cruise?

If we had to pick just one, September is the best month for a Mississippi River cruise. The weather is usually mild with less likelihood of rain, and autumn colors are beginning to paint the shoreline. Keep in mind, however, that the Mississippi is the fourth largest river in the world—so temperatures any time of year are not going to be the same in warmer Louisiana as they are in cooler Minnesota.

Below, see our favorite Mississippi River cruises to book in 2024, featuring stops in iconic American cities like Nashville , Memphis , and New Orleans .

22-day Mississippi River Odyssey: New Orleans to Red Wing, Minnesota

Enjoy the charms of America’s great river on a journey aboard the Viking Mississippi from New Orleans to Red Wing, departing September 20. Custom built to sail American waters, the vessel features river-facing staterooms with either French or step-out balconies.

Stops include Baton Rouge and St. Francisville in Louisiana; Natchez, Vicksburg, Greenville, and Rosedale in Mississippi; Memphis in Tennessee; Paducah in Kentucky; Cape Girardeau, St. Louis, and Hannibal in Missouri; Burlington, Quad Cities, and Dubuque in Iowa; La Crosse in Wisconsin; and ending in Red Wing, Minnesota.

With so many fascinating shore excursions to choose from, it’s well worth taking time to tour the St. Louis Arch . Opened in 1965, the monument to America’s westward expansion is far more than just a stunning photo by the riverside. Venture underground between the arch legs for a museum. Climb aboard a tram to be transported 630 feet up to the top of America’s tallest monument for some stunning views.

12-day Heart of the Delta: Memphis to New Orleans

The 386-guest Viking Mississippi spans five decks, making it one of the largest passenger vessels on the Mississippi. Inaugurated in 2022, the ship features a modern Scandinavian design with an infinity pool and a two-story Explorers’ Lounge observation area similar to its ocean ships. Directly in front of the Explorer’s Lounge is an expanded outdoor seating area known as The Bow. Three restaurants serve both Southern regional cuisine and international favorites.

The cruise starts in Memphis on November 14 and includes stops in Rosedale, Greenville, Vicksburg, and Natchez in Mississippi as well as St. Francisville, Baton Rouge, and Darrow in Louisiana, ending in New Orleans. The “Mississippi Sings the Blues” shore excursion visits iconic sites along the Mississippi Blues Trail such as historic Dockery Farms, considered the “birthplace of the blues.”

The tour stops in Clarksdale, the fabled “Crossroads” where legend says blues great Robert Johnson reputedly sold his soul to the devil in exchange for his guitar prowess. Stops at the GRAMMY Museum Mississippi and the Delta Blues Museum completes this perfect trip for music lovers.

9-day Music Cities Cruise: Nashville to Memphis

Music is the main focus of this cruise offered by American Cruise Lines, which begins in Nashville on July 9 with an unforgettable visit to the legendary Grand Ole Opry and ends in Memphis, where passengers will enjoy live music on Beale Street and a tour of Elvis Presley’s Graceland . On board the American Splendor, passengers will enjoy spacious cabins and popular rocking chairs. First inaugurated in 2016 and fully redecorated in 2022, this ship offers the nostalgia of a classic paddlewheeler along with the comfort of modern amenities.

While in Nashville, explore the Johnny Cash Museum, then walk upstairs to The Patsy Cline Museum. Nightly entertainment spotlights the musical heritage of this region as the world’s newest paddlewheeler journeys along the river. The itinerary also includes Clarksville and Dover in Tennessee plus Paducah in Kentucky. In Paducah, stroll along the riverfront with more than 50 life-sized panoramic murals depicting Paducah’s past. Stop by Paducah’s National Quilt Museum, the world’s largest museum devoted to quilt and fiber art.

23-day Complete Mississippi River Cruise: New Orleans to St. Paul

Sail 1,393 miles through 10 states on a comprehensive exploration of the mighty Mississippi on the new American Serenade . Inaugurated in 2023, the 91-cabin American Serenade won Best New River Cruise Ship of the Year 2023 by Cruise Critic , the first time an American ship has received this prestigious award.

“With extra-large all-balcony staterooms and suites, trendy interior décor, an innovative hydraulic bow and retractable ramp, and one of the most gorgeous sun decks we’ve seen on a river-going ship, American Serenade sets the bar for domestic US river cruising high,” the award notes.

The epic itinerary beginning July 18, 2024 includes 22 ports of call including Oak Alley, Houmas House, Baton Rouge, and St. Francisville in Louisiana; Natchez, Vicksburg, Greenville, and Tunica in Mississippi; Memphis in Tennessee; Cape Girardeau, St. Louis, and Hannibal in Missouri; Muscatine and Dubuque in Iowa; and Winona, Red Wing, and Saint Paul in Minnesota.

12-day Mississippi River Gateway Cruise: New Orleans to St. Louis

From the French Quarter in New Orleans to the towering Gateway Arch in St. Louis , this American Heritage cruise lives up to its name. Inaugurated in 2015 and totally redecorated in 2022, the 84-cabin American Heritage is the perfect vessel for this interesting itinerary, its design reminiscent of the days when steamboat paddlewheelers plied the Mississippi in the 1800s.

The 12-day voyage departs from New Orleans on July 2. Ports of call along the way include Baton Rouge in Louisiana; Natchez and Vicksburg in Mississippi; Memphis in Tennessee; and Paducah in Kentucky . An onboard expert shares tales of the importance of steam-driven paddlewheels in establishing riverfront communities along the great Mississippi River.

Step ashore in Natchez and enjoy a cold drink at the Under-the-Hill-Saloon, once one of the rowdiest establishments on the Mississippi River in the 1800s. Legend says that Mark Twain stopped here when he was just another riverman named Samuel Clemens.

9-day Lower Mississippi River Cruise: Memphis to New Orleans

This nine-day American Melody cruise departs Memphis on September 8 and features eight ports of call including Vicksburg and Natchez in Mississippi, and St. Francisville, Baton Rouge, and Houmas House in Louisiana. At Vicksburg Military Park, learn how the 101st Airborne Division got its “Screaming Eagles” nickname, plus the tale of its famous soldier, a young guitar player named Jimi Hendrix. At Houmas House, see the bedroom where Bette Davis stayed to film the 1964 movie Hush, Hush, Sweet Charlotte . Joan Crawford was the intended co-star but Bette and Joan feuded so Joan quit and Olivia de Havilland replaced her.

Launched in 2021, the five-deck American Melody has 91 staterooms, all with private balconies and full-length sliding glass doors. The ship has several spacious lounges, a fitness center, large dining room, café for casual dining, sun deck, library, and an impressive four-story glass atrium in the center of the ship. The ship’s unusual bow opens and lowers a platform for passengers to easily walk ashore.

9-day Upper Mississippi River Cruise: St. Louis to St. Paul

Board the American Symphony cruise ship to visit Mark Twain’s hometown and experience the real-life inspiration behind Life on the Mississippi, the classic memoir chronicling the author's days on the river as a steamboat pilot.

The 91-cabin American Symphony, recently inaugurated in 2022, has 100% private balcony accommodations and a unique bow that opens with a retractable gangway that can be extended for landings virtually anywhere. The ship also features lounges soaring 40 feet above the water with triple the glass of other riverboats for spectacular views. Comfy deck chairs welcome passengers to enjoy the undeveloped countryside, picturesque islands, and fascinating dams and navigation locks.

Departing September 27, this itinerary features seven ports of call including Muscatine and Dubuque in Iowa, and Winona and Red Wing in Minnesota. In Hannibal, visit the actual home—with a whitewashed Tom Sawyer fence—where Samuel Clemens (Mark Twain) grew up. In Dubuque, see the 1989 “Field of Dreams” movie site known for the famous quote, “If you build it, they will come.”

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7 best Mississippi River cruises

Mississippi River cruises have surged in popularity in recent decades. They are especially appealing to mature travelers looking to enjoy guided tours of top cities and small towns in several Southern and Midwestern states.

Add in regionally inspired cuisine enjoyed aboard a luxurious river ship, plus the camaraderie of other culturally curious travelers, and cruising the most celebrated river in the United States promises satisfaction on multiple levels.

Two major cruise lines sail the Mississippi, which stretches 2,340 miles from New Orleans to Minneapolis-St. Paul: American Cruise Lines and Viking . Each line offers several similar itineraries ranging from eight to 23 days, but the ships themselves differ. Some are retro-inspired paddlewheelers, others sleek modern riverboats. The onboard dining and entertainment, as well as the excursions in port, also vary across the lines.

For cruise news, reviews and tips, sign up for TPG's cruise newsletter .

We've rounded up the best Mississippi River cruises for seniors, history buffs and Americana lovers, so you can find your perfect U.S. river cruise itinerary based on your interests and travel preferences.

Best cruise for Civil War history: Lower Mississippi (round trip from New Orleans)

The Deep South attracts history buffs with its Civil War battlefields and cemeteries and 18th- and 19th-century mansions guarded by regiments of live oaks. Both cruise lines offer a Lower Mississippi river cruise, sailing round-trip from New Orleans, but only one features multiple excursions geared to those with a keen interest in the 19th-century conflict.

On American Cruise Lines' eight-day New Orleans to New Orleans itinerary , cruisers can visit Vicksburg, Mississippi, where the National Military Park commemorates the campaign, siege and defense of Vicksburg in 1863. In Louisiana's capital, Baton Rouge, a guided excursion explores critical locations in the Civil War's Battle of Baton Rouge and Port Hudson.

Other ports bring to life the pre-war South. In Oak Alley, Louisiana, guests can tour a Greek Revival mansion on a sugar plantation built and maintained by slaves. While no Civil War fighting took place in Natchez, Mississippi, the city is home to hundreds of lavish mansions from the era and the Historic Natchez Cemetery, which dates to 1822.

This itinerary is offered in 2024 and 2025 on four American Cruise Lines ships, ranging from the 150-passenger classic paddlewheeler American Heritage to the 180-passenger modern riverboat American Serenade. American Cruise Lines is known for its regionally inspired cuisine, served with complimentary wine and beer at lunch and dinner, plus complimentary cocktails, hors d'oeuvres and hosted entertainment in the main lounges.

Some excursions and a pre-cruise hotel stay in the Big Easy are included in the cruise fare. You can book additional day tours for an extra cost.

Related: Best river cruise lines around the world

If you're especially passionate about Civil War history, look for American Cruise Lines' special Civil War-themed cruises on limited dates, which allow a deeper dive into the period. These include a nine-day Lower Mississippi itinerary from Memphis to New Orleans (or vice versa).

In addition to visiting monuments and museums, you'll enjoy onboard lectures and presentations and interaction with other Civil War buffs. These sailings are aboard 150-passenger American Heritage and 180-guest American Melody, American Serenade, American Splendor and American Symphony.

Best cruise for music: Lower Mississippi (New Orleans to Memphis)

If you love the musical genres of the South, a Mississippi River cruise from New Orleans to Memphis (or vice versa) should be your choice.

From Crescent City, the birthplace of American jazz, to Memphis, known as the Home of the Blues and the Birthplace of Rock 'n Roll, this itinerary celebrates the region's homegrown rhythms. Both cruise lines offer itineraries between New Orleans and Memphis, but Viking features more excursions and onboard experiences tailored to music lovers.

Viking's 12-day Heart of the Delta itinerary includes a two-night pre-cruise hotel stay in New Orleans. This allows ample time to enjoy the city's street musicians and jazz clubs.

In Baton Rouge, you can visit the Capitol Park Museum, which showcases exhibits dedicated to Louisiana's musical heritage and Mardi Gras traditions. While in Natchez, Mississippi, classical music (played on a 1903 Steinway piano) and Southern cuisine are the stars of the excursion to Lansdowne and Joseph Stone House.

The port call in Greenville, Mississippi, is steeped in the blues with a chance to visit a museum dedicated to hometown legend B.B. King. The grand finale of the cruise is two nights in Memphis, where you can enjoy all things blues, barbecue and Elvis Presley.

Viking is a newcomer to the Mississippi River, and all sailings are aboard the 386-guest Viking Mississippi. The riverboat debuted in 2022 and features a modern Scandinavian design. Itinerary departures are available in 2024 and 2025.

Passengers can enjoy a sun terrace with an aft infinity pool and an Explorer's Lounge with panoramic forward views of the Mississippi. The Restaurant serves both Southern regional cuisine and global favorites, and the ship welcomes local musicians onboard for evening entertainment.

Related: Meet the only line that cruises from Washington, DC. Here's where it'll take you

Best cruise for art and architecture: Upper Mississippi

An Upper Mississippi cruise between St. Louis, Missouri, and St. Paul, Minnesota, provides access to some of the top architectural landmarks and artistic treasures of the American Heartland — from Eero Saarinen's soaring Gateway Arch to Frank Lloyd Wright's inimitable Taliesin.

Both cruise lines offer Upper Mississippi sailings from July through September. Viking and American Cruise Lines' itineraries and excursions are our picks for fans of American art and architecture.

Viking River Cruises' American Heartland itinerary sails from St. Louis to St. Paul (or vice versa) and runs 12 days with pre- and post-cruise stays in 2024 and 2025. You'll explore architectural gems aboard Viking Mississippi, itself an example of sleek, Scandinavian-inspired nautical architecture.

Highlights include St. Louis, where you'll admire Saarinen's circa-1965 Gateway Arch, the Cathedral Basilica of St. Louis featuring a 41-million-piece mosaic and the Renaissance Revival-style City Hall. From Dubuque, Iowa, you can head to Spring Green, Wisconsin, to visit Taliesin, Frank Lloyd Wright's private home, studio and school from 1911 to 1959.

After a day in Redwing, Minnesota, known for its pottery studios, you'll end your journey in the Twin Cities, home to the Walker Art Center and Minneapolis Institute of Art in Minneapolis and well-preserved Victorian buildings in St. Paul.

Related: River cruise packing list: What to pack when traveling by riverboat

American Cruise Line's nine-day Upper Mississippi river cruise covers much of the same ground, with a few differences. Sailings are available on the 150-passenger paddlewheeler American Heritage as well as on three sleek new 180-guest riverboats, American Melody, American Serenade and American Symphony. They're offered between June and late September/early October in 2024, 2025 and 2026.

Beyond the landmarks of St. Louis, highlights include Hannibal, Missouri, where you can visit the Mark Twain Boyhood Home and Museum, and Dubuque, Iowa, known for its colorful Victorian mansions. (An excursion to the Field of Dreams featured in the 1989 Kevin Costner movie is also available.)

Winona, Minnesota, boasts some of the state's most architecturally significant buildings, many featuring the beautiful stained glass for which the city is known. Then it's off to Red Wing, Minnesota, where you can explore the Pottery Museum before completing your journey in the Twin Cities.

Best extended cruise: Complete Mississippi

Want it all? You can visit 18 ports in six states on a 23-day Mississippi River journey from New Orleans to St. Paul. These itineraries are offered by both American Cruise Lines and Viking, and are perfect for seniors with plenty of time to explore.

American Cruise Lines offers the 23-day Complete Mississippi Cruise in 2024, 2025 and 2026, with sailings available on three 180-passenger modern river ships: American Melody, American Serenade and American Symphony.

After a pre-cruise hotel stay in New Orleans, passengers journey through all aspects of American history. You'll visit ports known for ornate mansions (Oak Alley and St. Francisville, Louisiana, and Natchez, Mississippi), Civil War battles (Baton Rouge, Louisiana and Vicksburg, Mississippi), music (Memphis and Greenville, Tennessee) and architecture (St. Louis and Dubuque, Iowa). You'll also call on a historic Missouri trading post in Cape Girardeau (a French river port).

Viking River Cruises' 22-day Grand Mississippi Voyage , available in 2024 aboard the 386-passenger Viking Mississippi, also embarks in New Orleans and visits 16 ports in nine states as it cruises north to St. Paul, Minnesota.

During this sailing, you'll overnight in Memphis, so there's time to fully savor barbecue, the blues and Elvis Presley's Graceland. A port call in Paducah, Kentucky, lets you explore the National Quilt Museum and colorful street murals.

You can enjoy excursions in Missouri's most famous big city (St. Louis) and small town (Hannibal) and then visit three ports in Iowa known for their historic architecture and agriculture (including a tour of the John Deere Pavilion). Learn about the Norwegian heritage of La Crosse, Wisconsin, and get to know the eagles and pottery of Red Wing, Minnesota, before disembarking in St. Paul.

Bottom line

History buffs and Americana lovers will find plenty to enjoy on a Mississippi River cruise. Your ship will stop in major cities and lesser-known towns, offering excursions to historic sites and evenings spent enjoying locally inspired cuisine and regional music.

The two cruise lines sailing America's most legendary river offer itineraries for every interest on ships designed with mature travelers in mind. Whether you want to visit Civil War sites, see top architectural landmarks or enjoy our country's best-loved musical genres, these two lines will offer a Mississippi River itinerary that will help you do it — in comfort and style as you make new friends on board.

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The 7 best mississippi river cruises for 2024.

Explore the history, culture and cuisine of the U.S. while cruising along the Mighty Mississippi.

The Best Mississippi River Cruises

Courtesy of American Cruise Lines

The more than 2,300-mile Mississippi River invites travelers to discover its multifaceted heritage, with a vast range of deeply rooted culture, music and history. A cruise is a fantastic way to discover many of the riverfront cities on a single trip, from the comfort of your modern riverboat or traditional paddle-wheeler.

The following Mississippi River cruise itineraries can help you choose from cruises of various lengths and options for the Lower and Upper Mississippi. Note that all fares are listed as double occupancy (based on two people per cabin), and that they might not reflect taxes, port fees or gratuities. The itinerary availability listed is also subject to change.

American Cruise Lines

Courtesy of American Cruise Lines | www.AmericanCruiseLines.com

American Cruise Lines operates small ships accommodating between 90 and 180 passengers that are built, flagged and crewed in the U.S. – and it's the only company in the world operating a 100% U.S.-flagged fleet of riverboats and cruise ships. ACL's itineraries traverse waterways across 35 states, with 11 itineraries dedicated to the Mississippi River. Cruisers can choose to sail on modern riverboats with a sleek interior design or while away their time aboard classic paddle-wheelers reminiscent of days gone by.

ACL offers variety as well as versatility: This line boasts both the longest and shortest sailings on this list with cruises ranging from eight to 60 days in length, including The Great United States. This inaugural 60-day voyage spans four major rivers and 20 states, making it the longest U.S. river cruise in history.

Complimentary hotel and transportation packages are available from every departure city before your cruise. You can book certain premium packages for added perks, such as two nights spent next door to Graceland in Memphis – with VIP tickets and a city tour included in the price.

Music Cities Cruise

Length: Eight days Price: Starts at $3,610 per person

Spend a week getting lost in the sounds of the Memphis blues, rock 'n' roll and country music legends on the seven-night Music Cities Cruise. A hotel stay the night before your sailing is included, but embarking in Memphis means you also have the chance to splurge on a two-night pre-cruise package near Elvis' former home Graceland .

Ports of call include Paducah, Kentucky; Dover, Tennessee; and Clarksville, Tennessee, with an overnight in Nashville and an included excursion to a show at the Grand Ole Opry. Two scenic sailing days feature picturesque views of America's Heartland along the Mississippi, Ohio and Cumberland rivers as well as Lake Barkley.

2024 dates: In 2024, there are two available itineraries in September and November.

Grand Heartland Cruise: St. Paul to New Orleans

Length: 15 days Price: Starts at $9,455 per person

This 15-day voyage allows you to explore America's rich history in towns along the Upper and Lower Mississippi River. The immersive voyage covers six states and 12 cities including St. Paul, Minnesota ; Dubuque, Iowa; St. Louis, Missouri ; Memphis, Tennessee; Natchez, Mississippi; Baton Rouge, Louisiana ; and more.

Take a step back in time while visiting Mark Twain's boyhood home in Hannibal, exploring stately historic estates in Natchez and Civil War sites in Vicksburg. At the end of a busy day ashore, you'll have plenty to chat about with fellow passengers during the evening cocktail hour.

2024 dates: American Heritage – ACL's traditional paddle-wheeler – and three modern riverboats set off on this journey from August to October in 2024.

Complete Mississippi River Cruise: New Orleans to St. Paul

Length: 22 days Price: Starts at $14,935 per person

If you want to see the entire Mississippi in one shot, check out this multiweek sailing that begins in New Orleans and ends in St. Paul, Minnesota. Along the way, you'll sail 1,393 miles, visit 10 states and experience a staggering 20 ports of call as you tour Louisiana and then head northbound to Minnesota.

In the South, walk the battlefields of the Civil War and sample delicious Southern barbecue before listening to the rhythms of jazz, the blues and rock 'n' roll. Then, explore the small and larger cities along the upper parts of the river. Remember to take time to gaze out at the picturesque scenery and the rolling farmlands of America's Midwest before disembarking in St. Paul.

2024 dates: Three of ACL's modern riverboats sail this itinerary in May, June and August in 2024.

The Great United States

Length: 60 days Price: Starts at $51,000

This two-month long journey – the longest domestic itinerary ever created – will check all the boxes for U.S. history and Civil War buffs, music and nature lovers, culinary enthusiasts, and beer and distilled spirits aficionados alike as the ship traverses America's iconic waterways through 20 states and 50 ports of call.

This epic journey showcases the natural beauty and living history of the U.S. from sea to shining sea. The sailing embarks in Portland, Oregon , on the Pacific Coast before traveling east to the Atlantic shore along four major rivers that highlight some of the country's most stunning coastlines. Upon arrival in New York Harbor, guests will have an unforgettable view of one of the most iconic landmarks in the U.S.: the Statue of Liberty .

Passengers can follow in the footsteps of Lewis and Clark along the Snake and Columbia rivers; cruise along Ol' Man River in search of Mark Twain and Elvis; see the vibrant colors of fall during peak season on the Hudson River; and take in the coastal breezes (and fresh seafood) along New England's rocky coastline.

This curated adventure also includes two flights: Jackson, Wyoming , to New Orleans as well as St. Paul to Portland, Maine , plus a land package through Glacier , Yellowstone and Grand Teton national parks. All-inclusive pricing covers the pre-cruise hotel stay, all flights and hotels between cruise segments, an ACL jacket and gear pack, daily excursions, all meals and beverages, gratuities and port charges, entertainment, and Wi-Fi.

2024 dates: The inaugural cruise sets sail on August 16, 2024.

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Viking River Cruises

Courtesy of Viking

Viking is no stranger to sailing Europe's rivers; the brand is synonymous with river cruising worldwide aboard its dozens of ships. However, Viking River Cruises is a newcomer to U.S. rivers, with its purpose-built ship: the 386-passenger Viking Mississippi. Looking to carve out its own niche in the American river cruising category, Viking claims it has the region's "first truly modern cruise ship" with its distinct Scandinavian design and expansive top sun deck with an infinity plunge pool.

Viking's mostly all-inclusive fares include a complimentary excursion in each port, destination lectures and performances, beer and wine at meals, free Wi-Fi, specialty coffees and teas, and more. The line offers five itineraries ranging in length from eight to 22 days along the Mighty Mississippi. Pre- and post-cruise extensions can be added to all voyages for an additional expense.

New Orleans & Southern Charms: Round-trip from New Orleans

Length: Eight days Price: Starts at $3,999 per person

If you don't know which Viking Mississippi itinerary to choose, start here. A round-trip voyage from New Orleans is convenient for booking flights and offers an excellent opportunity to extend your stay in NOLA. Six guided tours are included across eight days, from the historic estates of Natchez to Vicksburg National Military Park. A stop in St. Francisville gives you the chance to marvel at some of the 140-plus buildings it has on the National Register of Historic Places.

If you extend your stay in New Orleans, plan to sample the local Creole cuisine and take in some of the city's nightly jazz entertainment. In the morning, grab a beignet and a steaming cup of chicory coffee au lait at the original Café du Monde in the French Market.

2024 dates: This itinerary is available on select dates in February, November and December.

Heart of the Delta: New Orleans to Memphis

Length: Nine days Price: Starts at $4,299 per person

Similar to its round-trip New Orleans Southern Charms itinerary, the Heart of the Delta cruise begins in New Orleans and calls on the same five ports, before sailing through the Lower Mississippi and disembarking in Memphis. Enjoy scenic views of the serpentine river route – perhaps with expert commentary or a local cooking demonstration – and then take time to explore the birthplace of the Memphis blues, which is also a center of civil rights history.

2024 dates: In 2024, this cruise is available in February, March, April, May, June and November.

America's Great River: St. Paul to New Orleans

Length: 15 days Price: Starts at $12,999 per person

This Viking voyage sails from St. Paul to New Orleans on a two-week trip that calls on 13 ports with one day of scenic sailing. This itinerary combines the best of Viking's other Mississippi sailings for an all-encompassing Midwestern and Southern experience with 12 guided tours.

Included in the fare is a tour of Graceland; a stroll through small-town Burlington, Iowa, to see Snake Alley, deemed the most crooked street in the world; and a visit to the National Eagle Center of Red Wing, among others. For an additional fee, hop on an airboat ride through the Atchafalaya Swamp in Baton Rouge or tour the Anheuser-Busch Brewery of St. Louis.

2024 dates: Viking has availability for this itinerary in July, September and October.

Want to cruise the Mississippi River? See the top cruises on GoToSea , a service of U.S. News.

You may have seen riverboat gambling ships or are at least familiar with riverboat gambling along U.S. waterways. However, while high rolling on the river sounds like an exciting way to spend a night (or two, or more) while on your riverboat cruise, you'll have to jump ship to play the slots, roll the dice, spin the wheel or play a hand of Texas Hold 'em. Gambling on cruise ships sailing on internal waters is prohibited by U.S. law.

Gambling on boats in the U.S. is a complicated matter. While you will find some ships sailing along American waterways that are only set up for gambling, they are not carrying passengers from port to port. Most vessels that feature riverboat gambling are now moored, offering sports betting, table games, entertainment, live music and dancing while tethered to shore.

Why Trust U.S. News Travel

Gwen Pratesi has been an avid cruiser since her early 20s. She has sailed on nearly every type of cruise ship built, including the newest megaships, paddle-wheelers on America's waterways, and an 18-stateroom river ship on the Mekong River in Vietnam and Cambodia. Most recently, she traveled on a small luxury expedition vessel in Antarctica and crossed the notorious Drake Passage twice. She covers the travel and culinary industries, specializing in cruises, for major publications including U.S. News & World Report.

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Mississippi River Cruises

The Mississippi River is truly a force of nature and travels across multiple states in the USA such as Iowa or Illinois before flowing through the Gulf of Mexico. Being the fourth largest river in the USA means that a river cruise in Mississippi will reveal countless landmarks, breathtaking scenery and even wildlife. Discover premium river cruise companies and you've got yourself a dream holiday to relax and recharge.

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Tastes and Sounds of the South (10 Days)

A well planned and executed tour. Great way to see Nashville, Memphis, and New Orleans and learn the history of music during the day and listen to it at night.

• €100 deposit on some dates Some departure dates offer you the chance to book this tour with a lower deposit.

Tennessee Music Trail to New Orleans

Rhythms of the Road (including Hammond)

tour took us exactly where we wanted to go with someone else doing the organising!

America's Musical Heritage

Excellent organization in all respects, Peter was overwhelming.

America's Musical Heritage with Extended Stay in New Orleans

Rhythms of the South (11 Days)

Accommodation was great.The optional tours were well worth visiting. Lots of music. Loved the coach driver D-Henry, he was just great and very protective of his passengers. Guide Scott was good as well. Got a very good insight into the music scene. Learnt a lot.

Southern Sounds & Elvis

A great tour for music lovers. So much history and so much fun

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USA – New Orleans Mardi Gras Carnival

Bourbon, Beale & Broadway!

Got to be the best music tour ever! Brilliant holiday visiting the three most well known streets in America. Loads included, and loads to do and see - with plenty time to see everything. If you are looking for a value for money music cities tour - this is the one! Travelling Time - really look after you - and show you the meaning of great music holidays!

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Pictures and Stories From the Swamp

Country Roads of the Deep South (Classic, 12 Days)

Boundary Waters

Country Roads of the Deep South (Small Groups, 12 Days)

Southern Grace (Small Groups, 9 Days, Door To Door)

Reviews of mississippi cruises.

Would’ve loved it to have been longer! An extra night in each main city would’ve been great for extra activities

The trip was wonderful. The itinerary was excellent and there was a good balance between structured tours and free time. Our tour guide and driver were professional, personable and helpful.

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• River Cruises

What to Know About Mississippi River Cruises — From the Cruise Lines to Top Itineraries

See small towns and bustling cities by boat on a Mississippi River cruise.

Elizabeth Rhodes is a special projects editor at Travel + Leisure , covering everything from luxury hotels to theme parks to must-pack travel products. Originally from South Carolina, Elizabeth moved to New York City from London, where she started her career as a travel blogger and writer.

River cruises are a great way to see the world — you can visit several waterfront destinations and watch the scenery pass by from cozy accommodations and top-deck lounges on intimate luxury ships. And while rivers like the Danube and the Rhine are top choices for many travelers, you don't have to go abroad for a memorable river cruise. You can access some of the nation's iconic attractions and favorite cities right from the Mississippi River.

There are three main cruise lines traveling the Mississippi, with journeys ranging from less than a week to more than 20 days. Spring and fall are the best times of year to take a cruise along the river, as you'll avoid the summer heat and winter chill and enjoy more pleasant weather while you take in the surroundings.

Here's what you need to know about Mississippi River boat cruises, from choice itineraries to popular stops.

Mississippi River Cruise Lines

There are three main cruise lines that offer itineraries along the Mississippi River: Viking River Cruises , American Queen Voyages , and American Cruise Lines . Viking is known for its luxury river, ocean, and expedition cruises to incredible destinations around the world, and trips aboard its 193-stateroom Viking Mississippi adhere to the same standard of service.

American Queen Voyages offers several itineraries along the Mississippi — one along the Upper Mississippi, another on the Lower Mississippi, and one that also sails a portion of the Ohio River — on its signature paddle-wheel steamboats. The company's flagship, the American Queen, is said to be the world's biggest steamboat.

The itineraries on American Cruise Lines feature either modern riverboats or old-school paddle wheelers, so you can choose your ideal sailing experience.

All three cruise lines offer similar itineraries along the river, so we recommend looking into the ships, the amenities, and what's included in the rate (like pre-departure hotel stays and excursions) to help make your decision.

Popular Ports on the Mississippi

You can cruise all the way from New Orleans to Minneapolis, or you can sail shorter segments of the river. Typically, cruises along the Lower Mississippi sail between New Orleans and Memphis, while cruises on the Upper Mississippi sail between St. Louis and the Twin Cities.

Passengers on the Upper Mississippi may get the chance to hop off and explore Mark Twain's childhood home in Hannibal, Missouri, stroll the streets of Iowa's oldest city (Dubuque), or marvel at sacred bluffs in Red Wing, Minnesota. Along the Middle Mississippi, there's Paducah, Kentucky, a UNESCO-designated Creative City , and Chester, Illinois, the birthplace of Popeye the Sailor Man.

On the Lower Mississippi, you'll find Cajun culture in Baton Rouge, Louisiana, Civil War history in Vicksburg, Mississippi, and music and BBQ in Memphis .

Mississippi River Cruise Itineraries

There are many itineraries to choose from between the three major Mississippi River Cruise lines, but here are our top picks.

Viking River Cruises: America's Great River

Cruise from New Orleans all the way up to St. Paul on Viking's 15- or 17-day America's Great River itinerary aboard the 193-stateroom Viking Mississippi , a vessel designed just for this river. The journey starts in New Orleans and stops in Baton Rouge; Natchez and Vicksburg, Mississippi; Memphis; and St. Louis, where passengers can explore attractions like Gateway Arch National Park and the flagship Anheuser-Busch brewery. From there, it continues on to Hannibal, Missouri; Burlington, Davenport, and Dubuque, Iowa; La Crosse, Wisconsin; and Red Wing, Minnesota, where travelers can learn about America's most recognizable symbol at the National Eagle Center. In between action-packed stops, there's plenty of time to take in the scenery from your veranda or the boat's several public viewing areas.

American Queen Voyages: New Orleans to Memphis

Sail along the Lower Mississippi from New Orleans to Memphis on this nine-day cruise, which starts with a complimentary stay in New Orleans and a second day to enjoy the Big Easy. Then, it's on to Nottoway Resort and St. Francisville in Louisiana and Natchez, Vicksburg, and Greenville in Mississippi before a day of cruising through the Delta and disembarking in Memphis. There are a few different paddle-wheel riverboats that cruise this route for American Queen Voyages — find the specific ship for your journey when you select a date.

American Cruise Lines: Upper Mississippi River Cruise

This eight-day cruise starts in St. Louis and sails along the Upper Mississippi to St. Paul. Stops along the way include Hannibal, Missouri; Fort Madison, Davenport, and Dubuque, Iowa; and Winona and Red Wing, Minnesota. Several riverboats cruise this route, including American Melody and American Symphony , inaugurated in 2021 and 2022, respectively. These sister vessels offer large rooms and suites with contemporary furnishings and an upscale feel.

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Mississippi River Cruises

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About Mississippi River Cruises

One of the most important U.S. waterways, and one of the most colorful, is the mighty Mississippi River. On a Mississippi River cruise American history comes to life. The broad vistas take you through America's heartland, past beautifully restored antebellum plantations, and into incredible cities and towns. Explore civil war battlegrounds and the historical homes of Mark Twain and Abraham Lincoln.

Music is an integral part of the Mississippi River culture. There is no better place to experience the blues than in Memphis where you can visit the historical Graceland. Nashville brings country music alive at the Grand Ole Opry. Be surrounded by incredible Jazz surround in New Orleans. Let a Mississippi River cruise show you some of the best that America has to offer.

Best Mississippi River Cruise Deals

• Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!

• All Inclusive Cruising: FREE Wi-Fi, Shore Excursions & Beverages

All offers are based on select sailings and categories and are subject to availability at time of booking. All rates are per person based on double occupancy.

Due to the small ship size river cruises book up early and quickly. It is highly recommended to book your river cruise well in advance. All prices and availability are subject to change at any time. Please call to verify the availability and rates.

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Advanced public reservations are taken online. Bookings open four weeks in advance of cruise date.

La Crosse Queen Cruises

Paddlewheel cruises on the mississippi river.

Now taking reservations for private charters or groups of 30 or more on any public cruise for our 2024 season! Please call for more information. All other public cruise reservations open for booking four weeks prior to each cruise date. New to 2024 season: Captain’s Sunday Brunch Cruise departing at 10:30 a.m. and lasting until 1:00 p.m. Two-and-a-half hours will allow us to “lock thru” Lock & Dam No. 7, conditions permitting!

Individual public reservations will become available in Spring of 2021—Group reservations are now available for 2021.

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Saturday Dinner Cruise

Feast on a delicious chicken and prime rib dinner while relaxing on this Mississippi River tour!

• Clock 6:00 p.m.
• Users All ages
• Hour Glass 2.5 hours

Cruise on the Mighty Mississippi!

• Clock Wednesday's and Friday's at 5:30 p.m. & Saturday's and Sunday's at 3:30 p.m.
• Hour Glass 1.5 hours

Pizza Cruise

Enjoy an afternoon on the Mighty Mississippi River while eating free pizza on this fun boat tour!

• Clock 10:30 a.m.

Captain’s Sunday Brunch

Enjoy a delicious brunch while learning about the Mississippi River on this narrated river tour!

• Clock 11:00 a.m. & 1:30 p.m.

Sightseeing Cruise

Learn all about the historical and present day Mississippi River on this sightseeing cruise!

See the historical sites and local wildlife of the beautiful Upper Mississippi River!

Step back in time when you come aboard our replica paddlewheel river boat!

Choose from our tasty brunch, lunch, pizza, and dinner buffet-style cruises!

Beer, wine, and liquor offered on every cruise.

About La Crosse Queen Cruises

Cruise back in time and explore the Upper Mississippi with us! The La Crosse Queen is a modern-day replica of the grand river boats that plied the Mississippi River in the early 1900s. Cruising out of La Crosse, Wisconsin, she is one of the few authentic Mississippi River paddlewheel river boats still in operation in the United States today. In keeping with early traditions, she was built with sternwheels that are her only means of propulsion. 

The La Crosse Queen has a split sternwheel, and each half is run by a twin diesel engine that powers hydraulic motors, which turn the paddles. The split paddlewheel gives the Queen greater maneuverability and dependability. This is in contrast to most Mississippi River paddlewheelers in operation today that have a “free wheeling” paddlewheel at the stern of the boat for visual effect, but have traditional screw-type engines hidden for their real means of propulsion. 

The La Crosse Queen is U.S. Coast Guard inspected for safety and is licensed to carry up to 149 passengers.

The #1 Outdoor Activity in La Crosse on TripAdvisor

We took this boat cruise on a beautiful Saturday afternoon. The boat was full, but there was plenty of room. Drinks are very reasonable and the staff was knowledgeable and friendly. One big plus was the bathrooms were clean and spacious, something I didn't think I would find on a paddle boat! I would recommend the La Crosse Queen.

We took this cruise with a group and it was a lot of fun! We saw eagles, blue herons, foxes, osprey, along the banks of the Mississippi. We were able to go through the locks, which was lucky since if there is a barge in the area they do not allow this. We are talking about going again in the fall when the leaves are changing and birds are migrating.

We took the Friday night Pizza cruise and enjoyed fantastic views of the Mississippi River. Several people from our group had never been on a river cruise and were amazed. Free Pizza and beer along with cruise for $18.95 is hard to beat! Some questioned the cheap price, but soon found out it was good.

This was an excellent tour. The guide who did the narrative was friendly, fun and knowledgeable about the town and river. We saw bald eagles, a swing bridge, fancy homes, etc. We sat on the top deck which is covered and has open air sides so you get out of the sun and a nice breeze.

Always wanted to take a cruise on the Mississippi and we booked the early afternoon cruise on a weekday. Boarding went smoothly - they take your picture for sale later as a souvenir. Boat was clean and comfy and captain and staff friendly, helpful and knowledgeable. They do have a snack bar and bathrooms on board. Relaxing and enjoyable!

We went on the La Crosse Queen on a beautiful day. Cruising on the river was so cool. The breeze, scenery was awesome. Best place to view everything is on the top deck. The crew were so polite and fun to talk with. If you have questions they answered them. Hats off to the La Crosse Queen.

Wonderful time on a 2-hour Sunday Brunch cruise. The buffet was small but the price was still good. Met wonderful folks inside and outside during the trip. Got to go through a Lock and Dam. The wait staff were very accommodating. Definitely worth every penny for this adventure.

We celebrated our 23rd wedding anniversary on the La Crosse Queen. The dinner exceeded our expectations. The turkey and roast beef were both tender and moist. For being a buffet the food was delicious. The staff was attentive and live music was a surprise. We were fortunate to have wonderful weather and really enjoyed ourselves!

Phone 800 331-1467

1 – Day Cruise

AUGUST 8, 9, 10, 11, 30, 31    SEPTEMBER 1    OCTOBER 25, 26, 27, 28

Dubuque, Iowa to Guttenberg, Iowa & Return

Includes : Continental Breakfast, 2 Snacks, Full Lunch, Historical Narration, Great Scenery, Eagles, more relaxation than you have had in years,

$189 Adults     $89 Children 12 & Under 

Terms and conditions.

River Cruises reserves the right to cancel any cruise, change schedules or routes and substitute vessel without prior notice.

Cruises may be abbreviated, altered or cancelled, if in the judgement of the Captain, conditions are not conducive to the safe operations. Passengers, who by their actions, endanger themselves, other passengers, crew members, or the vessel, will be subject to arrest. 

• Know Before You Go

Trip Itinerary

This cruise heads North from Dubuque through Lock & Dam 11 and takes in one of the most beautiful areas of the Mississippi River. Your cruise includes continental breakfast, a mid-morning and mid-afternoon snack, and a full lunch. Take in historical narration, great scenery, wildlife, and live entertainment.

If river conditions allow, we will dock in Guttenberg and give our passengers the opportunity to depart the boat and spend time in this quaint, river town. Be sure to listen to the instructions from the Captain for the re-boarding time. Lunch will be served after we depart from Guttenberg. If we are unable to dock in Guttenberg, lunch will be served at approximately 12:15pm. Arrival time back at Dubuque is approximately 5:00pm.

Refunds for Cancellations

Less than 30 days’ notice of cancellation: $50 /person not refunded. – Less than 5 days notice: 50% refund. – Less than 24 hours’ notice, no-shows or late arrivals: no refund . An inconvenience fee of up to 50% of the cruise value may be charged for passengers who fail to show up for their scheduled cruise.  W e may allow you to reschedule, based upon availability.

All passage must be reserved in advance. No fares transacted at the boarding point. 

Boarding Location 450 E. 3rd St. Dubuque, IA 52001

Boarding time is 7:15 am at our dock in dubuque, iowa. departure time is 7:30 am sharp..

If you are running behind, call 1-800-331-1467 .

Free, ample parking  is available at our  boat dock  in Dubuque. Parking is well-lit and routinely patrolled by the local police. 

You may bring a backpack, purse, tote bag, or other carry-on bag onboard , with essential items you need during the day. Coolers are only allowed for medical use.

The Twilight offers ample, indoor and outdoor seating on all three decks. A gift shop and restrooms are located on the main deck; a cash bar is located on the third deck. Stair climbing is required to reach the upper decks.

An indoor, dining table is reserved for your party; we ask that you sit at your reserved table during mealtimes. You may roam throughout the boat during the duration of your trip.

Suggested Items to Bring with You

We recommend dressing in layers and wearing comfortable shoes. Consider bringing onboard items such as a camera, medication, binoculars, sunscreen, sunglasses, and or leisure items such as a book, board games, cards, etc. Charge your devices ahead of time; outlets are limited.

Accommodations & Requests

Please notify us in advance of any specific physical or dietary accommodations. We cannot guarantee requested changes less than 10 days prior to your cruise date.

Our chef can accommodate most special diets (e.g. diabetic, vegan/vegetarian, and gluten free). We cannot guarantee the availability of particular foods once the boat has left the dock. Call 1-800-331-1467 to request dietary accommodations. We encourage anyone with special dietary needs to  read our complete policy here.  Any questions? Call 1-800-331-1467 to request dietary accommodations.

The Twilight has three levels; stairs are required to reach the upper decks. We are unable to accommodate motorized scooters onboard; these can be sent with your overnight luggage and will be waiting for you at our dock in Dubuque. Walkers or wheelchairs are welcomed. If you need seating on the lowest level, an ADA room at the hotel, or any other physical accommodation, call 1-800-331-1467.

Hotel Recommendations (for before/after your trip)

These three hotels are closest to the Port of Dubuque . Additional, local accommodations can be found at https://www.traveldubuque.com/stay

Grand Harbor Resort – 563-690-4000

Hotel Julien Dubuque — 563-556-4200

Holiday Inn Dubuque   — 563-556-2000

If you are not vaccinated, we strongly encourage you to do so, however, at this time the Riverboat Twilight does not ask for proof of vaccination. Mask wearing is the choice of the individual. The Twilight offers ample indoor and outdoor seating on all three decks and plenty of fresh air.

We will continue to maintain our increased sanitization efforts of the TWILIGHT and our boarding facilities, and we continue to provide hand sanitizer aboard the boat and employ a strong air purifier that uses UVC lighting that has been proven to destroy viruses and other bacteria.

For the safety of our passengers and crew and to maintain proper cleanliness, we have implemented the following guidelines for parents of children under the age of 14. While onboard the vessel and when making use of our food and beverages services, children must be accompanied by an adult at all times. With your cooperation and understanding, we will be able to continue to offer a safe and enjoyable experience for everyone.

As an owner, of the Holiday Inn Express & Suites Le Claire, IA and the President of Great Lakes Management Group which manages the hotel’s day to day operations, I wanted to say thank you. The business relationship with the Riverboat Twilight and her passengers is valued and much appreciated. We all know businesses from every industry has been operating in a different environment the last 8 weeks and will encounter new changes in the future.

We continue to monitor the franchise, local, state and federal safety guidelines to insure our guest and staff safety. For example, we anticipate a few changes in the near future which will include the following: a plastic shield / barrier at the front desk check,  revised breakfast offerings without a buffet setting, hand sanitizer located in the lobby and all floors at the elevator landings, continued use of hospital grade products to clean and sanitize the guest rooms, individual sanitizer wipes as an in-room amenity, removal of all products in the rooms that are reusable for example, pens, pads, laundry bags, and throw pillows, these items will be available upon request. We hope to see you soon. Stay safe and healthy!

  Respectfully, Neil Densmore | President glmg | hotels

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The 7 Best Mississippi River Cruises for 2024

T he more than 2,300-mile Mississippi River invites travelers to discover its multifaceted heritage, with a vast range of deeply rooted culture, music and history. A cruise is a fantastic way to discover many of the riverfront cities on a single trip, from the comfort of your modern riverboat or traditional paddle-wheeler.

The following Mississippi River cruise itineraries can help you choose from cruises of various lengths and options for the Lower and Upper Mississippi. Note that all fares are listed as double occupancy (based on two people per cabin), and that they might not reflect taxes, port fees or gratuities. The itinerary availability listed is also subject to change.

American Cruise Lines

American Cruise Lines operates small ships accommodating between 90 and 180 passengers that are built, flagged and crewed in the U.S. – and it's the only company in the world operating a 100% U.S.-flagged fleet of riverboats and cruise ships. ACL's itineraries traverse waterways across 35 states, with 11 itineraries dedicated to the Mississippi River. Cruisers can choose to sail on modern riverboats with a sleek interior design or while away their time aboard classic paddle-wheelers reminiscent of days gone by.

ACL offers variety as well as versatility: This line boasts both the longest and shortest sailings on this list with cruises ranging from eight to 60 days in length, including The Great United States. This inaugural 60-day voyage spans four major rivers and 20 states, making it the longest U.S. river cruise in history.

Complimentary hotel and transportation packages are available from every departure city before your cruise. You can book certain premium packages for added perks, such as two nights spent next door to Graceland in Memphis – with VIP tickets and a city tour included in the price.

Music Cities Cruise

Length: Eight days

Price: Starts at $3,610 per person

Spend a week getting lost in the sounds of the Memphis blues, rock 'n' roll and country music legends on the seven-night Music Cities Cruise. A hotel stay the night before your sailing is included, but embarking in Memphis means you also have the chance to splurge on a two-night pre-cruise package near Elvis' former home Graceland .

Ports of call include Paducah, Kentucky; Dover, Tennessee; and Clarksville, Tennessee, with an overnight in Nashville and an included excursion to a show at the Grand Ole Opry. Two scenic sailing days feature picturesque views of America's Heartland along the Mississippi, Ohio and Cumberland rivers as well as Lake Barkley.

2024 dates: In 2024, there are two available itineraries in September and November.

Grand Heartland Cruise: St. Paul to New Orleans

Length: 15 days

Price: Starts at $9,455 per person

This 15-day voyage allows you to explore America's rich history in towns along the Upper and Lower Mississippi River. The immersive voyage covers six states and 12 cities including St. Paul, Minnesota ; Dubuque, Iowa; St. Louis, Missouri ; Memphis, Tennessee; Natchez, Mississippi; Baton Rouge, Louisiana ; and more.

Take a step back in time while visiting Mark Twain's boyhood home in Hannibal, exploring stately historic estates in Natchez and Civil War sites in Vicksburg. At the end of a busy day ashore, you'll have plenty to chat about with fellow passengers during the evening cocktail hour.

2024 dates: American Heritage – ACL's traditional paddle-wheeler – and three modern riverboats set off on this journey from August to October in 2024.

Complete Mississippi River Cruise: New Orleans to St. Paul

Length: 22 days

Price: Starts at $14,935 per person

If you want to see the entire Mississippi in one shot, check out this multiweek sailing that begins in New Orleans and ends in St. Paul, Minnesota. Along the way, you'll sail 1,393 miles, visit 10 states and experience a staggering 20 ports of call as you tour Louisiana and then head northbound to Minnesota.

In the South, walk the battlefields of the Civil War and sample delicious Southern barbecue before listening to the rhythms of jazz, the blues and rock 'n' roll. Then, explore the small and larger cities along the upper parts of the river. Remember to take time to gaze out at the picturesque scenery and the rolling farmlands of America's Midwest before disembarking in St. Paul.

2024 dates: Three of ACL's modern riverboats sail this itinerary in May, June and August in 2024.

The Great United States

Length: 60 days

Price: Starts at $51,000

This two-month long journey – the longest domestic itinerary ever created – will check all the boxes for U.S. history and Civil War buffs, music and nature lovers, culinary enthusiasts, and beer and distilled spirits aficionados alike as the ship traverses America's iconic waterways through 20 states and 50 ports of call.

This epic journey showcases the natural beauty and living history of the U.S. from sea to shining sea. The sailing embarks in Portland, Oregon , on the Pacific Coast before traveling east to the Atlantic shore along four major rivers that highlight some of the country's most stunning coastlines. Upon arrival in New York Harbor, guests will have an unforgettable view of one of the most iconic landmarks in the U.S.: the Statue of Liberty .

Passengers can follow in the footsteps of Lewis and Clark along the Snake and Columbia rivers; cruise along Ol' Man River in search of Mark Twain and Elvis; see the vibrant colors of fall during peak season on the Hudson River; and take in the coastal breezes (and fresh seafood) along New England's rocky coastline.

This curated adventure also includes two flights: Jackson, Wyoming , to New Orleans as well as St. Paul to Portland, Maine , plus a land package through Glacier , Yellowstone and Grand Teton national parks. All-inclusive pricing covers the pre-cruise hotel stay, all flights and hotels between cruise segments, an ACL jacket and gear pack, daily excursions, all meals and beverages, gratuities and port charges, entertainment, and Wi-Fi.

2024 dates: The inaugural cruise sets sail on August 16, 2024.

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Viking River Cruises

Viking is no stranger to sailing Europe's rivers; the brand is synonymous with river cruising worldwide aboard its dozens of ships. However, Viking River Cruises is a newcomer to U.S. rivers, with its purpose-built ship: the 386-passenger Viking Mississippi. Looking to carve out its own niche in the American river cruising category, Viking claims it has the region's "first truly modern cruise ship" with its distinct Scandinavian design and expansive top sun deck with an infinity plunge pool.

Viking's mostly all-inclusive fares include a complimentary excursion in each port, destination lectures and performances, beer and wine at meals, free Wi-Fi, specialty coffees and teas, and more. The line offers five itineraries ranging in length from eight to 22 days along the Mighty Mississippi. Pre- and post-cruise extensions can be added to all voyages for an additional expense.

New Orleans & Southern Charms: Round-trip from New Orleans

Price: Starts at $3,999 per person

If you don't know which Viking Mississippi itinerary to choose, start here. A round-trip voyage from New Orleans is convenient for booking flights and offers an excellent opportunity to extend your stay in NOLA. Six guided tours are included across eight days, from the historic estates of Natchez to Vicksburg National Military Park. A stop in St. Francisville gives you the chance to marvel at some of the 140-plus buildings it has on the National Register of Historic Places.

If you extend your stay in New Orleans, plan to sample the local Creole cuisine and take in some of the city's nightly jazz entertainment. In the morning, grab a beignet and a steaming cup of chicory coffee au lait at the original Café du Monde in the French Market.

2024 dates: This itinerary is available on select dates in February, November and December.

Heart of the Delta: New Orleans to Memphis

Length: Nine days

Price: Starts at $4,299 per person

Similar to its round-trip New Orleans Southern Charms itinerary, the Heart of the Delta cruise begins in New Orleans and calls on the same five ports, before sailing through the Lower Mississippi and disembarking in Memphis. Enjoy scenic views of the serpentine river route – perhaps with expert commentary or a local cooking demonstration – and then take time to explore the birthplace of the Memphis blues, which is also a center of civil rights history.

2024 dates: In 2024, this cruise is available in February, March, April, May, June and November.

America's Great River: St. Paul to New Orleans

Price: Starts at $12,999 per person

This Viking voyage sails from St. Paul to New Orleans on a two-week trip that calls on 13 ports with one day of scenic sailing. This itinerary combines the best of Viking's other Mississippi sailings for an all-encompassing Midwestern and Southern experience with 12 guided tours.

Included in the fare is a tour of Graceland; a stroll through small-town Burlington, Iowa, to see Snake Alley, deemed the most crooked street in the world; and a visit to the National Eagle Center of Red Wing, among others. For an additional fee, hop on an airboat ride through the Atchafalaya Swamp in Baton Rouge or tour the Anheuser-Busch Brewery of St. Louis.

2024 dates: Viking has availability for this itinerary in July, September and October.

Want to cruise the Mississippi River? See the top cruises on GoToSea , a service of U.S. News.

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Why Trust U.S. News Travel

Gwen Pratesi has been an avid cruiser since her early 20s. She has sailed on nearly every type of cruise ship built, including the newest megaships, paddle-wheelers on America's waterways, and an 18-stateroom river ship on the Mekong River in Vietnam and Cambodia. Most recently, she traveled on a small luxury expedition vessel in Antarctica and crossed the notorious Drake Passage twice. She covers the travel and culinary industries, specializing in cruises, for major publications including U.S. News & World Report.

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